Title of article
Synthesis and release kinetics of polymerisable ester drug conjugates: towards pH-responsive infection-resistant urinary biomaterials
Author/Authors
McCoy، نويسنده , , Colin P. and Irwin، نويسنده , , Nicola J. and Brady، نويسنده , , Christopher and Jones، نويسنده , , David S. and Andrews، نويسنده , , Gavin P. and Gorman، نويسنده , , Sean P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
2511
To page
2514
Abstract
Herein we report the synthesis, characterisation and hydrolytic release kinetics of a suite of novel, polymerisable ester quinolone conjugates with varying alkenyl chain lengths. Hydrolysis was shown to proceed up to 17-fold faster upon elevation of pH from neutral to pH 9.29, making these conjugates attractive for the development of ‘designer’ infection-resistant urinary biomaterials exploiting the increase in urine pH reported at the onset of catheter-associated infection to trigger drug release.
Keywords
Chain length , pH elevation , Ester hydrolysis , Drug-polymer conjugates
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884409
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