Title of article
A one-pot, three-component regiospecific synthesis of dispiropyrrolidines containing a thiophenone ring via 1,3-dipolar cycloaddition reactions of azomethine ylides
Author/Authors
Moghaddam، نويسنده , , Firouz Matloubi and Khodabakhshi، نويسنده , , Mohammad Reza and Ghahremannejad، نويسنده , , Zahra and Foroushani، نويسنده , , Behzad Koushki and Ng، نويسنده , , Seik Weng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
2520
To page
2524
Abstract
The synthesis of new dispiropyrrolidines containing a thiophenone ring has been achieved by a one-pot, three-component 1,3-dipolar cycloaddition reaction. Unsaturated thiophenone dipolarophiles were reacted with azomethine ylides, generated in situ from sarcosine and cycloketone derivatives (isatin, ninhydrin, acenaphthoquinone), to produce the corresponding cycloadducts in good yields (70–90%). The cycloaddition reaction was found to be highly regio- and diastereoselective.
Keywords
1 , 3-dipolar cycloaddition , Azomethine ylide , Three-component reaction , Spiro oxindole , Dispiropyrrolidine
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884413
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