Title of article
Synthesis and hydrolytic properties of thymidine boranomonophosphate
Author/Authors
Xu، نويسنده , , Zhihong and Sergueeva، نويسنده , , Zinaida A. and Shaw، نويسنده , , Barbara Ramsay Shaw، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
2882
To page
2885
Abstract
Detailed synthetic procedures of thymidine 5′-O-(P-borano)monophosphate (TMPB) via an H-phosphonate approach are reported. The hydrolytic properties of TMPB in pH 1.8 and 6.76 buffers at 22 or 37 °C were studied using LC–MS. One nucleoside product, thymidine, was observed, supporting cleavage at the P–O ester bond to release nucleoside and boranophosphate (O3P-BH3−3). Higher temperatures and acidic conditions increase the hydrolysis rates.
Keywords
Thymidine 5?-P-boranomonophosphate , Boranation , H-phosphonate , stability , Boron-modified nucleosides , LC–MS
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884572
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