Title of article
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
Author/Authors
Tsatsaroni، نويسنده , , Alexandra and Zoidis، نويسنده , , Grigoris and Zoumpoulakis، نويسنده , , Panagiotis and Tsotinis، نويسنده , , Andrew and Taylor، نويسنده , , Martin C. and Kelly، نويسنده , , John M. and Fytas، نويسنده , , George، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
3238
To page
3240
Abstract
An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented.
Keywords
E/Z conformational behaviour , Trypanocidal action , Lipophilic hydroxamic acid derivatives , NMR , Molecular modelling studies
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884716
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