Title of article
Studies directed towards the total synthesis of narbonolide: stereoselective synthesis of the C1–C15 chain
Author/Authors
Yadav، نويسنده , , Jhillu S. and Kavita، نويسنده , , Aala and Raghavendra Rao، نويسنده , , Kovvuri V. and Mohapatra، نويسنده , , Debendra K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
3329
To page
3331
Abstract
A stereoselective synthesis of the C1–C15 chain of narbonolide, a 14-membered macrolactone belonging to the pikromycin family of antibiotics is described. The key steps involved in this synthesis are desymmetrization of bicyclic olefin with Brown’s asymmetric hydroboration, Evans aldol reaction, Takai olefination and Yamaguchi esterification to yield the corresponding ester.
Keywords
macrolactone , Narbonolide , Evans aldol reaction , Yamaguchi esterification , desymmetrization
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884755
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