Title of article
N-Demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
Author/Authors
Vallejo، نويسنده , , Mariana G. and Ortega، نويسنده , , Maria Gabriela and Cabrera، نويسنده , , José L. and Agnese، نويسنده , , Alicia Mariel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
5197
To page
5200
Abstract
The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 μM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.
Keywords
Huperzia saururus , N-Demethyl-sauroxine , Acetylcholinesterase inhibition , Sauroxine NMR two dimensional data
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885547
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