Title of article
A practical synthesis of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane
Author/Authors
Beinat، نويسنده , , Corinne and Banister، نويسنده , , Samuel D. and McErlean، نويسنده , , Christopher S.P. and Kassiou، نويسنده , , Michael، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
5345
To page
5347
Abstract
The rigid piperazine homologue 2,5-diazabicyclo[2.2.1]heptane (DBH) finds extensive application in medicinal chemistry and pharmaceutical research, but access to this scaffold is non-trivial. This letter details a concise synthetic sequence that gives ready access to DBH on gram scale. The route features a Staudinger reduction of an azide to facilitate a transannular cyclisation
Keywords
Transannular cyclisation , Heterocycles , Nicotinic acetylcholine receptors , 2 , Amines
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885595
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