Title of article
A cytotoxic dimeric furanoheliangolide from Piptocoma rufescens
Author/Authors
Ren، نويسنده , , Yulin and Jiménez، نويسنده , , Francisco and Garcيa، نويسنده , , Ricardo and Mejيa، نويسنده , , Milciades and Chai، نويسنده , , Heebyung and Farnsworth، نويسنده , , Norman R. and Soejarto، نويسنده , , Djaja D. and Kinghorn، نويسنده , , A. Douglas، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
5457
To page
5460
Abstract
A new sesquiterpene lactone, rufescenolide C (1), the first furanoheliangolide dimer, was isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. Its structure was determined by interpretation of its spectroscopic data, with the absolute configuration being established by analysis of the CD spectrum. A plausible biogenesis of this dimer is proposed. This compound showed potent cytotoxicity with an IC50 value of 150 nM, when tested against HT-29 human colon cancer cells.
Keywords
Piptocoma rufescens , Furanoheliangolide dimer , cytotoxicity
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885620
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