Title of article
Reductive aldol-type reaction of α,β-unsaturated esters with aldehydes or ketones in the presence of Rh catalyst and Et2Zn
Author/Authors
Sato، نويسنده , , Kazuyuki and Isoda، نويسنده , , Motoyuki and Tokura، نويسنده , , Yoriko and Omura، نويسنده , , Keiko and Tarui، نويسنده , , Atsushi and Omote، نويسنده , , Masaaki and Kumadaki، نويسنده , , Itsumaro and Ando، نويسنده , , Akira، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
5913
To page
5915
Abstract
The reaction of RhCl(PPh3)3 with Et2Zn easily generated a rhodium–hydride complex (Rh−H) that added to α,β-unsaturated esters to form rhodium enolate complexes by formal 1,4-reduction. These rhodium enolates gave the corresponding Reformatsky-type reagents through transmetalation, and they reacted with various aldehydes and ketones to give reductive aldol-type products in good to excellent yields.
Keywords
Reductive aldol reaction , Diethyl zinc , RhCl(PPh3)3 , Reformatsky–Honda reaction , Rh–H complex
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886419
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