Title of article
Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation
Author/Authors
Wang، نويسنده , , Le and Wang، نويسنده , , Yan and Guo، نويسنده , , Fangxu and Zheng، نويسنده , , Yue and Bhadury، نويسنده , , Pinaki S. and Sun، نويسنده , , Zhihua، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
6053
To page
6056
Abstract
A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.
Keywords
1 , 3-Disubstituted benzenes , Formylation , Regioselective lithiation
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886480
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