Title of article
Synthetic study on neoponkoranol and its side chain epimer as potent α-glucosidase inhibitors, optimization of protecting group
Author/Authors
Liu، نويسنده , , Dan and Xie، نويسنده , , Weijia and Liu، نويسنده , , Long and Yao، نويسنده , , Hequan and Xu، نويسنده , , Jinyi and Tanabe، نويسنده , , Genzoh and Muraoka، نويسنده , , Osamu and Wu، نويسنده , , Xiaoming، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
6333
To page
6336
Abstract
Coupling reaction between thiosugar and triflate as the key protocol to synthesize neoponkoranol, a naturally occurring potent α-glucosidase inhibitor, and its related sulfonium salts was optimized by applying different esters as protecting group, with the yields of desired products being greatly improved. Our proposed mechanism of the coupling reaction indicated that the nucleophilicity of C3-hydroxyl moiety on monosaccharide structure is closely related to the reaction mode.
Keywords
Neoponkoranol , natural product , Synthetic study , Salacia , ?-Glucosidase inhibitor
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886621
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