Title of article
Toward the natural didemnaketal A: total synthesis of the isomer of didemnaketal A
Author/Authors
Peng، نويسنده , , Lei and Zhang، نويسنده , , Fu-Min and Yang، نويسنده , , Bing-Miao and Zhang، نويسنده , , Xiaobo and Liu، نويسنده , , Wenxing and Zhang، نويسنده , , Shu-Yu and Tu، نويسنده , , Yong-Qiang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
6514
To page
6516
Abstract
The total synthesis of isomer of didemnaketal A was achieved in 26 steps. The position of esters is switched at C7 and C8 with respect to their proposed position in natural didemnaketal A, which shows potent anti-HIV activity but so far has not been synthesized in the laboratory. Structural analysis of synthetic isomer of didemnaketal A indicates that the esters at C7 and C8 are correctly assigned, suggesting that the problems for the structural reassignment of natural didemnaketal A lie elsewhere.
Keywords
Didemnaketal A , Structural reassignment , total synthesis , isomer
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886756
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