Title of article
Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines
Author/Authors
Fujii، نويسنده , , Wataru and Toda، نويسنده , , Kazuya and Matsumoto، نويسنده , , Kiriko and Kawaguchi، نويسنده , , Koichiro and Kawahara، نويسنده , , Sei-ichi and Hattori، نويسنده , , Yasunao and Fujii، نويسنده , , Hiroshi and Makabe، نويسنده , , Hidefumi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
7188
To page
7192
Abstract
Total synthesis of prodelphinidin B1, B2, and B4 has been accomplished. The key step is Lewis acid-mediated equimolar condensations between an epigallocatechin and/or a gallocatechin nucleophile and an epigallocatechin and/or a gallocatechin electrophile. The antitumor effects of synthetic prodelphinidin B1–B4 against human PC-3 prostate cancer cell lines have been investigated. These compounds showed significant antitumor effects. Their activity seemed to be little bit stronger than EGCG and prodelphinidin B3, known antitumor agent.
Keywords
natural product , Anticancer agents , Polyphenols , Synthesis
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1887080
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