Recent advance in transition-metal-mediated trifluoromethylation for the construction of C(sp3)–CF3 bonds

In the past 5 years, transition-metal-mediated trifluoromethylation for the construction of various CF3-containing building blocks has been the focus of recent research in both industrial and academic communities. Progresses in the construction of C(sp2)–CF3 bonds and C(sp)–CF3 have been well reviewed. This Letter will focus on the cases of transition-metal-mediated C(sp3)–CF3 bond formation, which involves the trifluoromethylation of sp3-hybridized C–X bonds, alkyl organometallic reagents, sp3-hybridized C–H bonds, and alkene derivatives.