Title of article
Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives as novel anticancer nucleoside analogs
Author/Authors
Marc A. Labroli، نويسنده , , Marc A. and Dwyer، نويسنده , , Michael P. and Shen، نويسنده , , Ruichao and Popovici-Muller، نويسنده , , Janeta and Pu، نويسنده , , Qinglin and Richard، نويسنده , , Judson and Rosner، نويسنده , , Kristen and Paruch، نويسنده , , Kamil and Guzi، نويسنده , , Timothy J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
598
To page
602
Abstract
A novel class of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several synthetic routes were devised and implemented which relied upon either SN2 displacement or reductive amination to provide the desired derivatives.
Keywords
nucleoside , Gemcitabine , reductive amination , Anticancer
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1887734
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