Title of article
Synthesis of an azabicyclic framework towards (±)-actinophyllic acid
Author/Authors
Mortimer، نويسنده , , Danny and Whiting، نويسنده , , Matthew and Harrity، نويسنده , , Joseph P.A. and Jones، نويسنده , , Simon and Coldham، نويسنده , , Iain، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
1255
To page
1257
Abstract
Lewis acid mediated intramolecular Mannich reaction between an azocinone and a 3-formylindole was investigated as part of a study towards the synthesis of actinophyllic acid. The intramolecular Mannich reaction resulted in a single diastereomer of the 1-azabicyclo[4.2.1]nonan-5-one core framework, although single crystal X-ray structure analysis revealed that this had the undesired stereochemistry in comparison with the natural product.
Keywords
Mannich , indole , Actinophyllic acid , Azocinone
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888184
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