Title of article
The stereoselective total synthesis of PF1163A
Author/Authors
Kumar، نويسنده , , Harish and Reddy، نويسنده , , A. Srinivas and Reddy، نويسنده , , B.V. Subba، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
1519
To page
1522
Abstract
A stereoselective total synthesis of 13-membered macrocycle PF1163A, an antifungal agent, has been accomplished for the first time starting from d-xylose. This approach involves a diastereoselective allylation of lactal ether,3a reductive ring opening of tetrahydrofuran ring,3b asymmetric methylation reaction, Yamaguchi esterification, and ring closing metathesis as key steps.
Keywords
Antifungal agent , Evans methylation , Yamaguchi esterification , Ring closing metathesis
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888295
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