Title of article
Fries rearrangement: scalable synthesis of key fluoro building blocks 3-fluoro-4-methoxybenzoyl chloride and 1,2-diethoxy-3-fluorobenzene
Author/Authors
Swapnil G. Yerande، نويسنده , , Swapnil G. and Shendage، نويسنده , , Deepak M. and Wakchaure، نويسنده , , Prasad B. and Phadtare، نويسنده , , Ganesh R. and Bhoite، نويسنده , , Madhavrao Y. and Gangopadhyay، نويسنده , , Ashok Kumar and Nagarajan، نويسنده , , Kuppuswamy and Rupp، نويسنده , , Richard Helmut، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
2426
To page
2429
Abstract
Lewis acid catalyzed Fries rearrangement of 2-fluorophenyl acetate (3) was performed on kg scale. The ortho 5 and para 4 isomers obtained were separated in an industrially feasible way. Compound 4 was then converted into fluorinated building block 3-fluoro-4-methoxybenzoyl chloride (1) while compound 5 was converted into 1,2-diethoxy-3-fluorobenzene (2) in high yields.
Keywords
Lewis acid , acylation , Fries rearrangement , Dakin oxidation , Process development
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888963
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