Title of article
Palladium-catalyzed C3-selective mono-arylation of 4-hydroxycoumarin
Author/Authors
Yakushiji، نويسنده , , Fumika and Haramo، نويسنده , , Masako and Miyadera، نويسنده , , Yukari and Uchiyama، نويسنده , , Chihiro and Takayama، نويسنده , , Kentaro and Hayashi، نويسنده , , Yoshio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
3316
To page
3318
Abstract
4-Hydroxycoumarin (1) is a useful synthon in synthetic organic chemistry and a basic skeleton of several bioactive compounds. The direct functionalization of 1 with novel catalytic system would provide an efficient meaning for construction of a chemical library. Here, we developed a new catalytic system using palladium(II) acetate for the C3 regioselective mono-arylation of 1. The 3-mono-arylated and the 3,4-disubstituted coumarins were synthesized to enable derivatization. This palladium-catalyzed direct arylation of 1 is effective for rapid diversification and chemical library construction.
Keywords
palladium catalyst , arylation , 4-Hydroxycoumarin , regioselective , Direct functionalization
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889641
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