Title of article
Toward the total synthesis of a lagunamide B analogue
Author/Authors
Pal، نويسنده , , Sudip and Chakraborty، نويسنده , , Tushar Kanti، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
3469
To page
3472
Abstract
Lagunamides, isolated from a marine cyanobacterium Lyngbya majuscule found in Singapore, showed very potent activities against Plasmodium falciparum and murine leukemia cell line (P388). Herein, a concise synthetic approach toward the total synthesis of a lagunamide B analogue is discussed. Macrolactonization, HWE-olefination, and modified Crimmin’s aldol are some of the key reactions featured in this synthesis.
Keywords
macrolactonization , macrolactamization , 2-Methyl-6-nitrobenzoic anhydride (MNBA) , Crimmin’s aldol , Horner–Wadsworth–Emmons olefination
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889734
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