Title of article
Syntheses of nucleosides with 2′-spirolactam and 2′-spiropyrrolidine moieties as potential inhibitors of hepatitis C virus NS5B polymerase
Author/Authors
Dang، نويسنده , , Qun and Zhang، نويسنده , , Zhibo and Tang، نويسنده , , Bingyu and Song، نويسنده , , Yang and Wu، نويسنده , , Ling and Chen، نويسنده , , Tongqian and Bogen، نويسنده , , Stephane and Girijavallabhan، نويسنده , , Vinay and Olsen، نويسنده , , David B. and Meinke، نويسنده , , Peter T.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
3813
To page
3816
Abstract
To discover novel nucleosides as potential antiviral agents, 2′-spirolactam and 2′-spiropyrrolidine-containing nucleoside analogs were envisioned. Efficient synthetic routes were developed with an epoxide opening as the key step to establish the quaternary center at the 2′ position, leading to the design and synthesis of uridine analogs 8 and 21, prodrugs 13–16, and cytidine analog 11.
Keywords
Spiro-lactam , HCV NS5B , nucleoside , Prodrug , Spiro-pyrrolidine
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889958
Link To Document