Title of article
Electrophile-driven copper-catalyzed one-pot synthesis of 3-halogen quinoline derivatives
Author/Authors
Cheng، نويسنده , , Jie and Zhai، نويسنده , , Hong and Bai، نويسنده , , Jun and Tang، نويسنده , , Jun and Lv، نويسنده , , Ling and Sun، نويسنده , , Bei، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
4044
To page
4046
Abstract
A convenient and regioselective one-pot synthesis of 3-chloride or 3-bromide quinoline derivatives was achieved through a Grignard addition reaction by alkynyl Grignard regent to o-trifluoroacetyl aniline and a Cu(II)-catalyzed cyclization–halogenation tandem reaction with aqueous HCl or HBr as electrophilic reagent.
Keywords
Tandem reaction , 3-Halogen quinolines , One-pot , o-Trifluoroacetyl aniline , Copper
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890090
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