Review of recent advances in nucleophilic C–F bond-forming reactions at sp3 centers

Because of the broad utility of organofluorine compounds, efficient nucleophilic fluorination reactions are of high synthetic value. This is because fluoride is generally less costly, more readily available as its positron-emitting isotope (18F−), and has a higher specific activity than its ‘F+’ counterparts. New reactions for the construction of CF bonds, that make use of contemporary chemical methods, have only lately begun to emerge. This review provides a brief summary of some of the recent disclosures in transition metal-catalyzed fluorination reactions at sp3-hybridized carbon centers with nucleophilic fluoride sources.