Title of article
Total syntheses of (±)-cis- and (±)-trans-neocnidilides
Author/Authors
Surendra H. Mahadevegowda، نويسنده , , Surendra H. and Khan، نويسنده , , Faiz Ahmed، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
4400
To page
4403
Abstract
Total syntheses of two antimicrobial natural products (±)-cis-neocnidilide and (±)-trans-neocnidilide starting from a readily preparable cyclohexa[b]-fused 5-oxabicyclo[2.1.1]hexane derivative are presented. The diastereomeric tetrahydrofuran tricarboxylate epimers obtained from a BF3·OEt2 promoted Grob-type fragmentation of the oxa-bicycle derivative were converted into title natural products by employing pyridinium dichromate/acetic anhydride mediated bis-oxidative cleavage reaction.
Keywords
Antimicrobial , Phthalides , Grob-type fragmentation , Bis-oxidative cleavage , total synthesis
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890299
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