Title of article
Silyl triflate-accelerated additions of catalytically generated zinc acetylides to N-phenyl nitrones
Author/Authors
Downey، نويسنده , , C. Wade and Maxwell، نويسنده , , Erin N. and Confair، نويسنده , , Danielle N.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
4959
To page
4961
Abstract
Terminal alkynes readily form zinc acetylides in the presence of iPr2NEt and 20 mol % ZnBr2, then attack N-phenyl nitrones activated by trimethylsilyl trifluoromethanesulfonate. Deprotection with aqueous acid yields N-hydroxyl propargylamine. Yields are generally high for nitrones derived from aromatic aldehydes. Control experiments suggest that silyl triflate has a significant accelerating effect upon the reaction.
Keywords
Zinc acetylides , Nitrones , Silyl triflates , Propargyl amines
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890538
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