Title of article
A highly diastereoselective five-component synthesis of 1-(alkylimino)-5,5-dicyano-3a-aryloctahydro-3-oxacyclobuta[cd]pentalene-1a,2,5a,5b(2H,3aH)-tetracarboxylates
Author/Authors
Adib، نويسنده , , Mehdi and Sheikhi، نويسنده , , Ehsan and Haghshenas، نويسنده , , Pouyan and Rajai-Daryasarei، نويسنده , , Saideh and Bijanzadeh، نويسنده , , Hamid Reza and Zhu، نويسنده , , Long-Guan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
4983
To page
4986
Abstract
A novel one-pot, five-component synthesis of 1-(alkylimino)-5,5-dicyano-3a-aryloctahydro-3-oxacyclobuta[cd]pentalene-1a,2,5a,5b(2H,3aH)-tetracarboxylates is described. A mixture of phenacyl bromide, malononitrile, isocyanide, and two equivalents of a dialkyl acetylenedicarboxylate undergoes a novel 1:1:1:2 addition reaction at ambient temperature in absolute ethanol to produce diastereoselectively the title compounds in good yields.
Keywords
Isocyanides , Dialkyl acetylenedicarboxylates , Phenacyl bromides , multicomponent reactions , diastereoselective synthesis
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890546
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