Comparison of measurement of left ventricular ejection fraction by Tc-99m sestamibi first-pass angiography with electron beam computed tomography in patients with anterior wall acute myocardial infarction

The goal of this study was to compare measurements of left ventricular (LV) ejection fraction (EF) by first-pass radionuclide angiography (“first-pass angiography”) using technetium-99m (Tc-99m) sestamibi with those by contrast-enhanced electron beam computed tomography (“electron beam tomography”) as a reference technique in patients with an anterior wall acute myocardial infarction (AMI). Twenty-five patients with first Q-wave anterior wall AMI underwent paired electron beam tomographic and first-pass angiographic studies (mean, 1 day apart). Fourteen patients had 2 sets of measurements of the LVEF obtained by both methods (separated by at least 6 weeks), for a total of 39 paired measurements. LVEF by electron beam tomography was calculated from absolute systolic and diastolic LV chamber volumes. LV volumes by electron beam tomography were 199 ± 51 ml at end-diastole and 111 ± 42 ml at end-systole. Mean LVEF was 45 ± 11% by first-pass tomography and 46 ± 9% by electron beam tomography. The linear correlation coefficient between both methods was 0.82 (p <0.0001), with slope = 1.0, y-intercept = −1.1, and SEE = 6.1. The mean difference between the 2 methods was −0.7 ± 6.0 EF units (p = 0.75). The correlation between the differences and means of both methods was 0.34 (p = 0.04), indicating a trend for first-pass angiography to overestimate LVEF in the higher range. LVEFs measured by first-pass angiography in patients with abnormal LV geometry and contraction patterns caused by anterior wall AMI agree well with those measured by electron beam tomography in the clinically relevant range.