Title of article
Silyl trifluoromethanesulfonate-activated para-methoxybenzyl methyl ether as an alkylating agent for thiols and aryl ketones
Author/Authors
Downey، نويسنده , , C. Wade and Covington، نويسنده , , Sarah E. and Obenschain، نويسنده , , Derek C. and Halliday، نويسنده , , Evan and Rague، نويسنده , , James T. and Confair، نويسنده , , Danielle N.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
5213
To page
5215
Abstract
para-Methoxybenzyl methyl ether acts as an alkylating agent for thiols in the presence of trimethylsilyl trifluoromethanesulfonate and trialkylamine base in good yields (58–96%). Aryl ketones are alkylated under similar conditions, probably through an enol silane intermediate, also in high yields (67–95%). The active alkylating species is likely a p-methoxybenzyl cation.
Keywords
Methyl ethers , Silyl triflates , Alkylation , Enol silanes
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890648
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