Title of article
Silica gel-promoted convenient synthesis of 2-bromo-3-hydroxybenzoate derivatives
Author/Authors
Shinohara، نويسنده , , Hiroyuki and Sonoda، نويسنده , , Motohiro and Hayagane، نويسنده , , Naoya and Kita، نويسنده , , Shota and Tanimori، نويسنده , , Shinji and Ogawa، نويسنده , , Akiya، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
5302
To page
5305
Abstract
A convenient silica gel-promoted synthesis of 2-bromo-3-hydroxybenzoate derivatives has been developed via the Diels–Alder reaction of furans with methyl 3-bromopropiolate, followed by a ring-opening aromatization. In addition, 2-bromo-3-methoxybenzoate, derived from 2-bromo-3-hydroxybenzoate with iodomethane, was found to be a good substrate for Pd-catalyzed cross-coupling reactions, despite its sterically hindered structure.
Keywords
furan , Silica gel , Diels–Alder reaction , Ring-opening aromatization , 2-Bromo-3-hydroxybenzoate
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890709
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