Title of article
Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme
Author/Authors
Bayat، نويسنده , , Saadi and Abd Malek، نويسنده , , Emilia and Yahaya، نويسنده , , Normi M. and Salleh، نويسنده , , Abu Bakar and Tejo، نويسنده , , Bimo Ario and Abdul Rahman، نويسنده , , Mohd Basyaruddin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
6303
To page
6306
Abstract
The promiscuous aldo–ketoreductase (AKR) enzyme is used as a sustainable biocatalyst for the first time to catalyze asymmetric aldol reactions in aqueous medium. The reactions between aromatic aldehydes and cyclic/acyclic ketones give the corresponding products in moderate yields and enantioselectivities in the presence of water. The influence of solvents, the mole ratio of substrates, and enzyme concentration are investigated. The mechanism of the AKR1A1-catalyzed aldol reaction is also discussed.
Keywords
Promiscuous enzymes , aldol reaction , asymmetric , Aldo–ketoreductase
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891173
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