Title of article
A practical total synthesis of (+)-isogalbulin and (+)-galbulin
Author/Authors
Li، نويسنده , , Xiaoyu and Jiao، نويسنده , , Xiaozhen and Liu، نويسنده , , Xiaoyu and Tian، نويسنده , , Chengsen and Dong، نويسنده , , Liang-Feng Yao، نويسنده , , Yangyang and Xie، نويسنده , , Ping، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
6324
To page
6327
Abstract
A practical total synthesis of the natural products (+)-isogalbulin and (+)-galbulin has been achieved in 10 steps from readily available 3-(3,4-dimethoxyphenyl)propanoic acid. The total yields were 12.3% and 12.9%, respectively. The key steps involved Evans asymmetric alkylation, Sharpless asymmetric epoxidation, and a highly regioselective opening of 1-benzyloxy-2,3-epoxides with an organoaluminum ate-complex formed by Me3Al and n-BuLi.
Keywords
(+)-Isogalbulin , (+)-Galbulin , Evans asymmetric alkylation , Sharpless asymmetric epoxidation , Bimolecular nucleophilic substitution
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891181
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