Title of article
Synthesis and antiproliferative activity of RITA and its analogs
Author/Authors
Jiang، نويسنده , , Jianhua and Ding، نويسنده , , Chao and Li، نويسنده , , Lulu and Gao، نويسنده , , Chunmei and Jiang، نويسنده , , Yuyang and Tan، نويسنده , , Chunyan and Hua، نويسنده , , Ruimao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
6635
To page
6638
Abstract
The synthesis of RITA and a variety of five-membered heterocyclic triads by the cyclocondensation of 1,4-bis(5-substituted-2-thienyl or 2-furyl)-1,3-butadiynes with water or Na2S·9H2O in the presence of KOH in DMSO is described. The study on the antiproliferative activities against K562, MCF-7, A549, and HCT116 tumor cells has revealed that some of the heterocyclic triads show higher antiproliferative activities than RITA, depending on the structures of substituents, the property of heteroatoms as well as their numbers.
Keywords
Heterocyclic triads , cyclocondensation , RITA , 1 , Antiproliferative activity , 3-butadiynes
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891322
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