Title of article
A new pyrrolidine-derived atropisomeric amino alcohol as a highly efficient chiral ligand for the asymmetric addition of diethylzinc to aldehydes
Author/Authors
Faigl، نويسنده , , Ferenc and Erdélyi، نويسنده , , Zsuzsa and Deلk، نويسنده , , Szilvia and Nyerges، نويسنده , , Miklَs and Mلtravِlgyi، نويسنده , , Béla، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
6891
To page
6894
Abstract
A highly efficient pyrrolidine-derived atropisomeric amino alcohol, (Sa)-1-[2-diphenylhydroxymethyl-6-(trifluoromethyl)phenyl]-2-(1-pyrrolido)methyl-1H-pyrrole, has been synthesized as a chiral ligand for the enantioselective addition of diethylzinc to some prochiral aldehydes to afford (S)-alcohols. The conversion rates were close to quantitative with good to excellent enantiomeric excesses (up to 95% ee).
Keywords
amino alcohol , axial chirality , enantioselective addition , Asymmetric catalysis , chiral ligand
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891421
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