Surgical methods to reverse left ventricular remodeling in congestive heart failure

In this review article, we describe the most common surgical procedures currently used to reverse or arrest remodeling of the left ventricle in patients with congestive heart failure (CHF). The selection of the appropriate operation in a patient is a complex decision-making process, rigorously based on pathophysiologic considerations. In this population, all factors affecting the surgical risk should be carefully evaluated preoperatively, and surgery should be recommended when definite benefits in survival and quality of life can be reasonably predicted. Quite often, patients with CHF require a combination of different procedures to address all the pathophysiologic components determining the clinical picture. In particular, in this review we describe the surgical restoration of the left ventricle, the isolated coronary artery bypass graft procedure, the correction of mitral regurgitation, diastolic support (from dynamic cardiomyoplasty to passive containment), and mechanical assist devices. Moreover, in the future, the role of surgery in the treatment of CHF will be strongly modified by the advent of gene therapy, cell therapy, and engineered artificial myocardial tissue.