Effect of oral l-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries

Thirteen hypertensive patients with microvascular angina were studied before and after receiving oral l-arginine (4 weeks, 2 g, 3 times daily). l-arginine significantly improved angina class, systolic blood pressure at rest, and quality of life. Maximal forearm blood flow, plasma l-arginine, l-arginine:asymmetric dimethyl arginine ratio, and cyclic guanylate monophosphate increased significantly after treatment. In medically treated hypertensive patients with micro-vascular angina, oral l-arginine may represent a useful therapeutic option.