Effect of oral l-arginine on oxidant stress, endothelial dysfunction, and systemic arterial pressure in young cardiac transplant recipients

Oral l-arginine therapy reverses endothelial dysfunction and attenuates high blood pressure in hypertensive cardiac transplant recipients. l-arginine corrects derangements in the vascular endothelial nitric oxide (NO)-dependent signaling pathway. Our data support the concept that cardiac transplant recipients use excess endogenous NO from l-arginine supplementation to buffer increased vascular oxidant stress.