Air stability of supported lipid membrane spots

Air-stability of supported lipid membranes is crucial to large scale applications of lipid membrane based biosensors and microarrays. Here we examined the air-stability of supported lipid membrane spots, and found that it was dependent on spot size. The smaller the lipid spot is, the more resistant to deterioration caused by air exposure it is, probably due to increased stable edge of small bilayer spots. This study suggests a strategy to design air-stable biomembrane based biosensors for biosensing applications.