One-step method for monodisperse microbiogels by glass capillary microfluidics

We present a novel one-step method to generate monodisperse microbiogel encapsulations. Both gelatin and alginate microbiogels are obtained by simply drying the middle oil phase of W/O/W double emulsion templates formed by a glass capillary microfluidics technique. We monitor the release of encapsulated proteins in the microbiogels at three different temperatures including physiological temperature (37 °C), and find the release of the encapsulants can be regulated by controlling the temperature. This one-step method provides a significant guide for the production of size-controllable microbiogels encapsulating various active ingredients.