Comparative inhibitory properties of some Indian medicinal plant extracts against photosensitization-induced lipid damage

The protective activities of Emblica officinalis, Terminalia bellerica and Terminalia chebula ethanol extracts against photosensitization-induced oxidation of rat liver mitochondrial lipid were assessed. All the extracts could effectively prevent lipid peroxidation, as assessed by measuring thiobarbituric acid-reactive substrates, lipid hydroperoxide, conjugated diene and 4-hydroxynonenal. The E. officinalis extract was the most potent, revealing its superior ability to scavenge 1O2. The extracts also afforded excellent protection against iron-mediated lipid peroxidation that might also be useful in reducing photo-induced iron toxicity. The activities of the extracts were primarily due to their constituent phenolics.