Sinigrin suppresses nitric oxide production in rats administered intraperitoneally with lipopolysaccharide

Sinigrin, a glucosinolate contained in cruciferous vegetables, is converted to allyl isothiocyanate by plant myrosinase or microbial myrosinase in gut microflora. The intake of sinigrin significantly decreases the urinary nitrate + nitrite level (a nitric oxide [NO] production marker) in rats administered intraperitoneally with lipopolysaccharide (LPS). This result demonstrates that sinigrin suppresses NO production and therefore likely has an antioxidative effect in vivo.