Title of article
Synthesis, characterization and cholinesterase enzymes inhibitory activity of 1-[3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-4,5-dihydro-pyrazol-1-yl]-ethanone
Author/Authors
Mehdi، نويسنده , , Sayed Hasan and Ghalib، نويسنده , , Raza Murad and Hashim، نويسنده , , Rokiah and da Silva، نويسنده , , M. Fلtima C. Guedes and Sulaiman، نويسنده , , Othman and Murugaiyah، نويسنده , , Vikneswaran and Marimuthu، نويسنده , , Mani Maran and Naqvi، نويسنده , , Mehnaz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
6
From page
488
To page
493
Abstract
The crystal structure of the title compound, 1-[3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-4,5-dihydro-pyrazol-1-yl]-ethanone has been determined by single crystal X-ray diffraction. It crystallizes in the orthorhombic space group P212121. The FTIR as well as the 1H and 13C NMR spectra of the compound were also recorded and briefly discussed. Compound 1 demonstrated good inhibitory activity against butyrylcholinesterase (BChE; IC50 = 46.42 μM) comparable to physostigmine. However it showed moderate inhibitory activity against acetylcholinesterase (AChE; IC50 = 157.31 μM). It showed moderate inhibitory activity against acetylcholinesterase and selective inhibitory activity towards butyrylcholinesterase enzyme.
Keywords
NMR spectra , Acetylcholinesterase , Butyrylcholinesterase , 1-H , 6 , 5-dihydro-pyrazol-1-yl]-ethanone , crystal structure , Inter-molecular hydrogen bonding , 6-trimethyl-cyclohex-1-enyl)-4
Journal title
Journal of Molecular Structure
Serial Year
2013
Journal title
Journal of Molecular Structure
Record number
1974619
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