Adsorption of various antimicrobial agents to endotoxin removal polymyxin-B immobilized fiber (Toraymyxin®). Part 2: Adsorption of two drugs to Toraymyxin PMX-20R cartridges

In our previous study, the degree of adsorption of 9 representative antimicrobial agents to Toraymyxin® PMX-F sheets was quantitatively evaluated [1]. As a result, the adsorption rate was 22.1% for Linezolid in the presence of serum. ore, we investigated whether two types of antimicrobial agents (Ciprofroxacin and Linezolid) can be better adsorbed on PMX-F sheets. When the number of PMX-F sheets was increased in a step wise manner, specifically 2, 4, 6, 8 and 12, the adsorption rate increased linearly. ition, the adsorption to polymyxin-B immobilized fiber (Toraymyxin® PMX-20R) cartridges, widely used to remove endotoxins from circulating blood in the treatment of sepsis, was quantitatively evaluated. As a result, in the presence of serum, Linezolid showed adsorption to PMX-20R, and the adsorption rate after 2 h was 54.5%, and that after 4 h was 65.8%. sults of this study suggest the necessity of monitoring blood antimicrobial concentration during treatment for sepsis with Linezolid, which showed adsorption to PMX-20R in an environment close to a clinical environment.