Title of article
Structure–activity relationship of carbamate-linked cationic lipids bearing hydroxyethyl headgroup for gene delivery
Author/Authors
Zhi، نويسنده , , Defu and Zhang، نويسنده , , Shubiao and Qureshi، نويسنده , , Farooq and Zhao، نويسنده , , Yinan and Cui، نويسنده , , Shaohui and Wang، نويسنده , , Bing and Chen، نويسنده , , Huiying and Yang، نويسنده , , Baoling and Zhao، نويسنده , , Defeng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
5
From page
537
To page
541
Abstract
A novel series of carbamate-linked cationic lipids containing hydroxyl headgroup were synthesized and included in formulations for transfection assays. The DNA–lipid complexes were characterized for their ability to bind DNA, their size, ζ-potential and cytotoxicity. Compared with our previously reported cationic transfection lipid DDCDMA lacking the hydroxyl group and the commercially available, these cationic liposomes exhibited relatively higher transfection efficiency.
Keywords
Carbamate-linked cationic lipids , Hydroxyl group , Transfection efficiency , gene delivery , cytotoxicity
Journal title
Colloids and Surfaces B Biointerfaces
Serial Year
2013
Journal title
Colloids and Surfaces B Biointerfaces
Record number
1977648
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