Solubility of pure taxol in supercritical carbon dioxide

The solubility of taxol in supercritical carbon dioxide was measured using a high-pressure ultraviolet–visible-light-transmission static cell at pressures from 3000 psia to 7000 psia and temperatures 35°C to 45°C. The solubility of taxol increased by a factor of seven from 0.7×10−7 to 5.0×10−7 mole fraction from 3000 psia to 7000 psia. The experimental data were modeled using the Peng–Robinson equation of state and the Chrastil method. The Peng–Robinson equation of state method utilizing k12 optimum did not provide an adequate fit. The Chrastil method provided a good fit with average absolute relative deviations of 4.6%, 3.6%, and 2.8% for 35°C, 40°C, and 45°C, respectively.