Solubilities of betulin in chloroform + methanol mixed solvents at T = (278.2, 288.2, 293.2, 298.2, 308.2 and 313.2) K

Experimental solubilities of betulin in mixed solvents of chloroform (1) + methanol (2) were determined at T = (278.2, 288.2, 293.2, 298.2, 308.2 and 313.2) K. The solubilities of betulin in mixed solvents of chloroform (1) + methanol (2) increase with increasing of temperature. The curves of solubility versus solvent composition on solute-free basis went through a maximum. Experimental data of solubilities were correlated with a three-parameter equation. In addition, three crystals of betulin obtained in different compositions of chloroform (1) + methanol (2) mixtures were characterized by scanning electron microscope (SEM) and differential scanning calorimetry (DSC).