Solid–liquid equilibrium and thermodynamic of 2,5-thiophenedicarboxylic acid in different organic solvents

In this paper, the solid–liquid equilibrium of 2,5-thiophenedicarboxylic acid in methanol, ethanol, i-propanol, n-butanol, acetic acid, n-hexane, acetonitrile and acetone was explored from 278.15 K to 333.15 K under atmosphere pressure. Modified Apelblat equation and λh equation were adopted to describe and predict the change tendency of solubility. Besides, the thermodynamic properties of the dissolution process, including enthalpy, entropy and Gibbs energy, were calculated by means of van’t Hoff analysis and Gibbs equation. Based on the analysis above, ethanol is considered to be the best solvent in crystallization process of 2,5-thiophenedicarboxylic acid.