Title of article
Immunity to viral haemorrhagic septicaemia (VHS) following DNA vaccination of rainbow trout at an early life-stage
Author/Authors
Lorenzen، نويسنده , , Niels and Lorenzen، نويسنده , , ELLEN and EINER-JENSEN، نويسنده , , Katja، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
7
From page
585
To page
591
Abstract
Rainbow trout fry of average weight 0·5 g were vaccinated against viral haemorrhagic septicaemia (VHS) by intramuscular injection of 1 μg of plasmid DNA encoding the VHS virus glycoprotein gene. Challenge with a lethal dose of virus at two different time points, 9 and 71 days post-vaccination respectively, revealed that a highly protective and lasting immunity was established shortly after vaccination, in accordance with earlier experiments with larger fish. The defence mechanisms activated by the DNA vaccine are thus functional at an early life-stage in rainbow trout.
Keywords
Rhabdovirus , genetic immunisation , rainbow trout fry , Plasmid DNA , early immunity
Journal title
Fish and Shellfish Immunology
Serial Year
2001
Journal title
Fish and Shellfish Immunology
Record number
2106660
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