Title of article
The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
Author/Authors
-، - نويسنده Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Eftekharzadeh, Mina , -، - نويسنده Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran|Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Nobakht, Maliheh , -، - نويسنده Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Alizadeh, Akram , -، - نويسنده Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran|Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Medical Genetics and Molecular Biology, Iran Soleimani, Mansooreh , -، - نويسنده Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Hajghasem, Mahmood , -، - نويسنده Department of Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Kordestani Shargh, Bahareh , -، - نويسنده Eposcience Millennium Institute, Tehran, Iran Karkuki Osguei, Nushin , -، - نويسنده Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Medical Genetics and Molecular Biology, Iran University of Medical Sciences, Tehran, Iran Behnam, Babak , -، - نويسنده Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Samadikuchaksaraei, Ali
Issue Information
فصلنامه با شماره پیاپی 0 سال 2015
Pages
6
From page
520
To page
525
Abstract
-
Abstract
Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimerʹs disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment ofAlzheimer’s disease in rat model.
Journal title
Iranian Journal of Basic Medical Sciences
Serial Year
2015
Journal title
Iranian Journal of Basic Medical Sciences
Record number
2160436
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