Title of article
Association of the Promoter Methylation of Mitochondrial Transcription Factor A With Susceptibility to Metabolic Syndrome
Author/Authors
Hashemi، Mohammad نويسنده , , Rezaei، Hamzeh نويسنده Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran , , Ali Kaykhaei، Mahmoud نويسنده Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran , , Taheri، Mohsen نويسنده Genetics of Non-communicable Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran Taheri, Mohsen
Issue Information
فصلنامه با شماره پیاپی 0 سال 2014
Pages
1
From page
0
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0
Abstract
It has been proposed that the patients with mitochondrial diseases usually manifest systemic metabolic disorders. The metabolic syndrome (MeS), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type 2 diabetes (T2D) and cardiovascular disease. The aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor A (TFAM) and MeS. DNA was extracted from peripheral blood of 151 patients with and 149 without MeS. TFAM promoter methylation was evaluated by a nested methylation-specific PCR (nested MSP). No association was found between TFAM promoter methylation and MeS. The present study suggests that the TFAM promoter methylation is not associated with risk of MeS.
Journal title
Gene Cell Tissue
Serial Year
2014
Journal title
Gene Cell Tissue
Record number
2230208
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