Hydrotropes

Previous views on hydrotropic solubilization as a matter of pair wise complexation between solubilizate and hydrotrope molecule have become modified during the past year. Three main discoveries concerning hydrotropes have been made: first, vapor pressures of solubilized molecules show a variation in vapor pressure more in line with nonspecific colloidal aggregates; second, the action of hydrotropes as ‘coupling agents’ has been shown to be due to simple disordering of long distance order aggregates; and third, hydrotropes have been demonstrated to be efficient and useful solubilizing agents in the preparation of vesicle solutions.